Curriculum Vitae
Mich Bradley Hein
Address:
Education:
1984 Ph.D., Plant Physiology University of Minnesota, St. Paul, MN,
1980 M.S., Plant Physiology University of Minnesota, St. Paul, MN,
1976 B.S., Botany Honors Tutorial College, Ohio University, Athens, OH,
Professional Experience:
EPIcyte Pharmaceutical, Inc., San Diego, CA (1996-Present)
Current Position: President and Director
The Scripps Research Institute, La Jolla, CA (1990-1997)
Current Position: Adjunct Member, Department of Cell Biology
Previous Positions: Assistant Member, Department of Cell Biology
Previous Positions: Assistant Professor, Graduate Program in Cellular and
Macromolecular Chemistry and Biology
PPG Industries, La Jolla, CA (1986-1990)
Position: Research Chemist and Laboratory Director for Plant Molecular Biology
Monsanto Company, St. Louis, MO (1982-1986)
Position: Research Chemist and Project Leader
Patents:
6/17/97 United States Patent 5,639,947
Publications:
1. Daie, J., Wyse, R., Hein, M. and Brenner, M.L. (1984). Abscisic acid metabolism by source and sink tissues of sugar beet. Plant Physiol. 74:810-814.
2. Hein, M.B., Brenner, M.L. and Brun, W.A. (1984). Concentrations of abscisic acid and indole-3-acetic acid in soybean seeds during development. Plant Physiol. 76:951-954.
3. Hein, M.B., Brenner, M.L. and Brun, W.A. (1984). Effects of pod removal on the transport and accumulation of abscisic acid and indole-3-acetic in soybean leaves. Plant Physiol. 76:955-958.
4. Davis, G.C., Hein, M.B., Neely, B.C., Sharp, C.R. and Carnes, M.G. (1985). Strategies for the determination of plant hormones. Anal. Chem. 57:638A-648A.
5. Davis, G. C., M. B. Hein, D.A. Chapman, B.C. Neely, C.R. Sharp, R.C. Durley, D.K. Biest, B.R. Heyde, and M.B. Carnes. (1985). Immunoaffinity columns for the isolation and analysis of plant hormones. In Plant Growth Substances, ed. M. Bopp, Springer-Verlag, Berling. pp 44-51.
6. Barry, G.F., Rogers, S.G., Hein, M.B., Niedermeyer, J.G., Hoffman, N.L., Blatt, L.M., Fraley, R.T., Sharp, C.R. and Horsch, R.B. (1985) Identification of cytokinkin genes and transfer into plants. Current Topics in Plant Biochemistry and Physiology. 4:101-110.
7. Hein, M.B., Brenner, M.L. and Brun, W.A. (1986). Accumulation of 14C-radiolabel in leaves and fruits after injection of [14C] tryptophan into seeds of soybean. Plant Physiol. 82:454-456.
8. Tricoli, D.M., Hein, M.B. and Carnes, M.G. (1986). Culture of soybean mesophyll protoplasts in alginate beads. Plant Cell Reports 5:334-337.
9. Davis, G.C., Hein, M.B. and Chapman, D.A. (1986). Evaluation of immunosorbents for the analysis of small molecules: Isolation and purification of cytokinins. J. Chromatogr, 366:171-189.
10. Klee, H.J., Horsch, R.B., Hinchee, M.A., Hein, M.B. and Hoffman, N.L. (1987). The effects of overproduction of two Agrobacterium tumefaciens T-DNA auxin biosynthetic gene products in transgenic petunia plants. Genes & Dev. 1:86-96.
11. Rajasekaran, K., Hein, M.B. and Vasil, I.K. (1987). Endogenous abscisic acid and indole-3-acetic acid in somatic embryogenesis and cultured leaf explants of Pennisetum purpureum Schaum. Plant Physiol. 84:47-51.
12. Rajasekaran, K., Hein, M.B., Davis, G.C., Carnes, M.G. and Vasil, I.K. (1987). Endogenous growth regulators in leaves and tissue culture of Pennisetum purpureum Schaum. J. Plant Physiol. 130:13-25.
13. Romano, C.P., Hein, M.B. and Klee, H.J. (1991). Inactivation of auxin in tobacco with the indoleacetic acid-lysine synthetase gene of Pseudomonas savastonoi. Genes and Development 5(3):438-446.
14. Hein, M.B., Tang, Y., McLeod, D.A., Janda, K.D. and Hiatt, A.H. (1991). Evaluation of immunoglobulins from plant cells. Biotech. Prog. 7:455-461.
15. Hiatt, A.C., Tang, Y., Weiser, W. and Hein, M.B. (1992). Assembly of antibodies and mutagenized variants in transgenic plants and plant cell cultures. Genetic Engineering 14:49-64.
16. Hiatt, A.C., and Hein, M.B. (1994). Structure, function and uses of antibodies from transgenic plants and animals. In: M Rosenberg and G.P. Moore (eds). Handbook of Experimental Pharmacology, Springer-Verlag, Heidelberg, Germany 113:317-330.
17. Ma, J.K.-C., Hiatt, A., Hein, M., Vine, N. Wang, F., Stabila, P., van Dolleweerd, C., Mostov, K., and Lehner, T. (1995). Generation and assembly of secretory antibodies in plants. Science 268: 716-719.
18. Fitchen, J., Beachy, R.N., and Hein, M.B. (1995). plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response. Vaccine 13: 1051-1057
19. Ma, J.K.-C, and Hein, M.B. (1995). Plant antibodies for immunotherapy. Plant Physiol. 109:341-346
20. Ma, J.K.-C., and Hein, M.B. (1995). Immunotherapeutic potential of plant antibodies. Trends in Biotechnol. 13: 522-527.
21. Beachy, R.N., Fitchen, J., Hein, M.B. (1996). Use of plant viruses for delivery of vaccine epitopes. Annals N.Y. Acad. Sci. 792: 43-49.
22. Hein, M.B., Yeo, C., Wang, F., Sturtevant, A. (1996) Expression of cholera toxin subunits in plants. Annals N.Y. Acad. Sci. 792: 50-56.
23. Ma, J. K.-C., Hein, M.B. (1996). Antibody production and engineering in plants. Annals N.Y. Acad. Sci. 792: 70-81.
24. Zimmerman, Z.A., and Hein, M.B. (1997). Oral intubation with psophocarpus tetragonolobus lectins results in stimulation of lectin-specific serum and mucosal antibodies. (submitted).